Yep, OTE literally had scenarios based on meta gaming as a premise.If there's one game that deserves to survive contact with the realms of metaplay, it's Over The Edge. Back in the day when I ran second edition, players made up some fantastically meta characters. It's a feature of a lot of the source material people mentioned above.
To answer the OP, 2nd edition of OtE is probably my favourite rpg ever. But these days my preferences lean towards scene resolution mechanics more than they used to, so I use 3rd Ed and season to taste with whatever of the eleventy-megabillion 2nd ed pdfs work for whatever's going on.
The shiny new book is lovely and shiny too.